LogoCompound
Jacketed reactor vessels in an industrial chemical manufacturing plant with stainless steel surfaces and overhead piping
Toll Manufacturing · Custom Synthesis · Scale-Up

Custom synthesis
at industrial scale.
No shortcuts.

From bench formula to 20,000-liter batch — reactor-grade intermediates and specialty blends for agrochemical, pharmaceutical, and performance-coatings applications.

View Case Studies
50,000 L
Maximum reactor capacity
160+
Synthesis routes qualified
99.4%
On-spec delivery rate
FDA-Audited
Pharmaceutical-grade documentation

Trusted by the companies behind the compounds you depend on.

BASFChemical
CortevaAgriscience
AshlandSpecialty Chem.
EvonikIndustries
LanxessSpecialty Chem.
ClariantSpecialty Chem.
CabotCorporation
Case Study 01 · Custom Synthesis
The Constraint

A crop-protection active with a six-week delivery window and no existing contract manufacturer.

A Midwest agrochemical firm had a registered active ingredient with a pending EPA registration review. Their incumbent supplier had shuttered a product line mid-contract. The compound required a three-step synthesis with a moisture-sensitive intermediate — and the client needed 4,200 kg of finished active in six weeks.

The Manufacturing Solution

Compound's process engineers reviewed the bench protocol and resequenced the synthesis to use two 5,000 L glass-lined reactors in parallel, eliminating a bottleneck at the deprotection step. Nitrogen-blanketed transfer lines were installed within 72 hours. Inline FTIR monitoring was added at Stage 2 to catch the moisture-sensitive intermediate before workup.

  • Glass-lined 5,000 L reactor × 2, parallel configuration
  • Nitrogen-blanketed transfer with continuous dew-point monitoring
  • Inline FTIR at Stage 2 — real-time purity confirmation
  • Daily QC reports issued to client's R&D team
The Outcome
98.7%
Assay purity
vs. 97.5% spec
39 days
First delivery
3 days ahead of deadline
−12%
Cost per kilo
vs. client's prior supplier
Glass-lined reactor vessel interior with stainless steel agitator and process connections in a chemical manufacturing facility

Glass-lined 5,000 L reactor — Building 3, Plant Floor B

Custom SynthesisMoisture-Sensitive ChemistryInline Analytics
GMP-Certified · ISO 9001 · FDA-Audited

Ready to discuss your manufacturing challenge?

Our process engineers review every inquiry within one business day. Bring the spec sheet — we'll bring the reactor time.

Case Study 02 · Hazardous Material Handling
GMP-grade chemical packaging line with sealed containment enclosures and automated filling equipment in a hazardous materials certified facility

Class III containment packaging — GMP Building 7

OSHA PSM CompliantClass III ContainmentDOT Hazmat Certified
The Constraint

A pharmaceutical excipient requiring chlorination — and a supply chain that couldn't afford a single failed audit.

A European pharmaceutical company needed a chlorinated intermediate for a Phase III drug substance. Their U.S. distributor had flagged the incumbent CMO for documentation gaps during an FDA pre-approval inspection. The client needed a replacement manufacturer who could pass a short-notice FDA audit and produce 800 kg within 10 weeks.

The Manufacturing Solution

Compound's quality team initiated a gap assessment against ICH Q7 within 48 hours of engagement. The chlorination step was run in a dedicated Class III containment reactor with scrubbed HCl off-gas capture. Full electronic batch records were issued in eCTD-compatible format. A mock FDA audit was conducted internally two weeks before the scheduled inspection.

  • ICH Q7 gap assessment completed in 48 hours
  • Dedicated chlorination reactor with HCl scrubber
  • Electronic batch records in eCTD-compatible format
  • Mock FDA audit passed with zero critical observations
The Outcome
0
FDA audit observations
Zero critical, zero major
9 wks
First delivery
One week ahead of schedule
99.1%
Chlorination yield
vs. 97.0% spec minimum
Case Study 03 · Regulatory Complexity
The Constraint

A novel performance-coating resin with REACH registration requirements and a 90-day regulatory clock.

A specialty coatings R&D team at a mid-market firm had a bench-scale resin formula showing exceptional adhesion on aluminum substrates. To commercialize in the EU, the compound required REACH registration. Their internal team had never managed a CMO-led REACH submission. Production needed to be EU-REACH compliant before a key OEM trial in Germany.

The Manufacturing Solution

Compound assigned a dedicated regulatory affairs liaison to coordinate with the client's EU-based legal team. The synthesis was run at 2,000 L pilot scale to generate the test substance required for REACH registration dossier. Analytical data packages — including OECD 301B biodegradability and Ames test results — were compiled by Compound's in-house analytical team and submitted within the 90-day window.

  • Dedicated regulatory liaison assigned from day one
  • 2,000 L pilot scale run for REACH test substance
  • OECD 301B and Ames test data packages compiled in-house
  • REACH dossier submitted 11 days ahead of deadline
The Outcome
79 days
REACH dossier submitted
11 days ahead of deadline
97.8%
Resin purity at pilot scale
Matches bench formula
3×
Scale-up path confirmed
To 6,000 L production batch
Inline analytical dashboard showing real-time chromatography data and process parameters on industrial monitoring screens in a chemical plant control room

Process analytics — Pilot Scale Control Room

REACH CompliantPilot ScaleRegulatory Affairs Support
Core Capabilities

Every capability built for
industrial-grade consequence.

Compound operates a 340,000 sq ft production facility in the Ohio River Valley with 24-hour manned operations, on-site QC laboratory, and dedicated regulatory affairs staff. We do not subcontract synthesis. Every batch is made here.

Custom Synthesis

Multi-step organic synthesis from milligram feasibility through metric-ton production. Specialty reagents, complex intermediates, proprietary blends.

  • 1 L – 50,000 L reactor range
  • Glass-lined & Hastelloy vessels
  • Cryogenic to 250°C

GMP Manufacturing

ICH Q7-aligned pharmaceutical manufacturing with full electronic batch records, change control, and FDA-audit-ready documentation.

  • FDA-audited facility
  • ICH Q7 compliant
  • eCTD-compatible batch records

Hazardous Chemistry

Chlorination, nitration, hydrogenation, and phosgenation in dedicated containment reactors with engineered safety systems.

  • Class I Div 2 classified areas
  • OSHA PSM compliant
  • DOT Hazmat certified packaging

Analytical Services

In-house HPLC, GC-MS, FTIR, Karl Fischer, ICP-OES, and particle size analysis. CoA issued with every batch.

  • Inline process analytics
  • Third-party verification available
  • Method development & transfer

Scale-Up Engineering

Structured scale-up from bench to pilot to production with documented process parameter mapping at each stage.

  • DoE-driven optimization
  • Yield & cycle time modeling
  • Technology transfer packages

Regulatory Support

Dedicated regulatory affairs team supporting REACH, TSCA, EPA registrations, and drug master file (DMF) submissions.

  • REACH dossier compilation
  • DMF authoring & maintenance
  • Pre-inspection readiness reviews
Certifications & RegistrationsISO 9001:2015ISO 14001FDA-Registered FacilityICH Q7 GMPOSHA PSMREACH AuthorizedTSCA CompliantDOT Hazmat
Capabilities PDF

Still in the evaluation phase?
Take our capabilities document with you.

A 12-page technical overview covering reactor specifications, process chemistry capabilities, QC methodology, regulatory certifications, and representative synthesis routes. Formatted for internal circulation to procurement and technical teams.

  • Reactor fleet specifications and capacity table
  • Supported chemistry classes and hazard categories
  • QC instrumentation and analytical capabilities
  • Regulatory certifications and audit history summary
  • Sample batch record structure and documentation package

Compound Capabilities Overview

12 pages · PDF · Updated Feb 2026

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